Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 6/20 | 0.62 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985381 | 0.81 | PTGS1 (0.60) | PTGS1PTGS2 | |
| SCHEMBL8985240 | 0.80 | PTGS2 (0.69) | PTGS1PTGS2 | |
| SCHEMBL514483 | 0.78 | HSD17B10 (0.56) | GSK3BNPC1RAB9AKDM4ENR2F2 | |
| SCHEMBL8985431 | 0.77 | PTGS1 (1.00) | PTGS1PTGS2 | |
| SCHEMBL8985534 | 0.77 | PTGS1 (0.71) | PTGS1PTGS2RAB9A | |
| SCHEMBL10567384 | 0.77 | PTGS1 (1.00) | PTGS1PTGS2 | |
| SCHEMBL8985333 | 0.77 | GSK3B (0.42) | PTGS1GSK3BPTGS2NPC1RAB9A | |
| SCHEMBL8985460 | 0.77 | PTGS2 (0.46) | PTGS1GSK3BPTGS2NPC1RAB9A | |
| SCHEMBL6517923 | 0.75 | PTGS1 (0.68) | PTGS1GSK3BPTGS2 | |
| SCHEMBL8985432 | 0.74 | MAPK14 (0.46) | PTGS1GSK3BPTGS2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571810-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, COLLAGEN DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-11-05 | — | — | US | disclosed |
| EP-0593761-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |
| WO-1991019708-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-26 | — | — | WO | disclosed |