Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.45 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | DCK | P27707 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16398962 | 0.86 | PTPN11 (0.49) | TRPM8KDM4EGAARAB9AALOX5 | |
| SCHEMBL820915 | 0.86 | PPARA (0.49) | TRPM8KDM4EGAARAB9APPARA | |
| SCHEMBL4034919 | 0.86 | RARA (0.49) | TRPM8GAARAB9AALOX5ALDH1A1 | |
| SCHEMBL5102703 | 0.82 | MAPT (0.52) | KDM4EGAARAB9APPARAMEN1 | |
| SCHEMBL15349239 | 0.82 | RARB (0.61) | KDM4EGAARAB9AMEN1ALDH1A1 | |
| SCHEMBL15933446 | 0.82 | DCK (0.45) | TRPM8KDM4EGAARAB9APPARA | |
| SCHEMBL8989133 | 0.82 | MPO (0.43) | TRPM8KDM4EGAARAB9APPARA | |
| SCHEMBL16603179 | 0.81 | KDM4E (0.49) | KDM4EGAAPPARAMEN1ALDH1A1 | |
| SCHEMBL12875931 | 0.80 | ALDH1A1 (0.46) | TRPM8RAB9APPARAMEN1ALDH1A1 | |
| SCHEMBL4462240 | 0.80 | KDM4E (0.57) | TRPM8KDM4EGAARAB9APPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545645-A | Heterocyclic derivatives in the treatment of ischaemia and related diseases | SYNTEX PHARMACEUTICALS, LIMITED (GB) | 1996-08-13 | — | — | US | disclosed |
| US-5428037-A | Piperazine derivatives; calcium and sodium channel antagonists | SYNTEX PHARMACEUTICALS, LTD. (GB) | 1995-06-27 | — | — | US | disclosed |