⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL510112 | 0.80 | — | — | |
| SCHEMBL476049 | 0.74 | ALDH1A1 (0.32) | — | |
| SCHEMBL8764997 | 0.74 | ALDH1A1 (0.32) | — | |
| SCHEMBL510221 | 0.72 | — | — | |
| SCHEMBL575023 | 0.72 | SMN1; SMN2 (0.32) | — | |
| SCHEMBL625136 | 0.72 | SMN1; SMN2 (0.32) | — | |
| SCHEMBL15974800 | 0.72 | — | — | |
| SCHEMBL8345909 | 0.72 | PRKCA (0.52) | — | |
| SCHEMBL5159977 | 0.72 | ALDH1A1 (0.33) | — | |
| SCHEMBL9321649 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563250-A | Cleavable conjugates for the delivery and release of agents in native form | NEORX CORPORATION (US) | 1996-10-08 | — | — | US | disclosed |
| US-5141648-A | Methods for isolating compounds using cleavable linker bound matrices | NEORX CORPORATION (US) | 1992-08-25 | — | — | US | disclosed |
| US-5017693-A | Methods for introducing a sulfhydryl amino or hydroxyl groups to a compound | NEORX CORPORATION (US) | 1991-05-21 | — | — | US | disclosed |
| WO-1990014844-A2 | SUGARS AS CLEAVABLE LINKERS FOR THE DELIVERY AND RELEASE OF AGENTS IN NATIVE FORM | NEORX CORPORATION (US) | 1990-12-13 | — | — | WO | disclosed |
| EP-0318948-A2 | Cleavable immunoconjugates for the delivery and release of agents in native form | NEORX CORPORATION (US) | 1989-06-07 | — | — | EP | disclosed |