SCHEMBL625136

SCHEMBL625136

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nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.32
ALDH1A1 P00352 1/20 0.31
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL575023 1.00 SMN1; SMN2 (0.32) SMN1; SMN2ALDH1A1TSHR
SCHEMBL29049316 0.80 SMN1; SMN2 (0.31) SMN1; SMN2ALDH1A1TSHR
SCHEMBL3852439 0.80 ALDH1A1 (0.32) SMN1; SMN2ALDH1A1TSHR
SCHEMBL476049 0.79 ALDH1A1 (0.32) ALDH1A1
SCHEMBL8764997 0.79 ALDH1A1 (0.32) ALDH1A1
SCHEMBL12567309 0.78 ALDH1A1 (0.33) SMN1; SMN2ALDH1A1TSHR
SCHEMBL11158482 0.78 ALDH1A1 (0.33) SMN1; SMN2ALDH1A1TSHR
SCHEMBL10965455 0.78 SMN1; SMN2 (0.30) SMN1; SMN2
SCHEMBL10873860 0.78 SMN1; SMN2 (0.30) SMN1; SMN2
SCHEMBL1985795 0.78 CA1 (0.35) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 412 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240238432-A1 METHOD FOR GLYCOPROTEIN MODIFICATION HONEYBEAR BIOSCIENCES INC. (TW) 2024-07-18 US claimed
WO-2024145600-A1 METHOD FOR GLYCOPROTEIN MODIFICATION HONEYBEAR BIOSCIENCES INC. (TW) 2024-07-04 WO claimed
US-20200190199-A1 ANTIBODY-DRUG CONJUGATES AND USES THEREOF DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) 2020-06-18 US claimed
EP-2032172-B1 LEPTOMYCIN DERIVATIVES SANOFI SA (FR) 2012-06-06 EP claimed
EP-2386559-A1 Cytotoxiv agents comprising new tomaymycin derivatives and their therapeutic use SANOFI (FR) 2011-11-16 EP claimed
US-20110254808-A1 REFLECTIVE TOUCH DISPLAY PANEL AND MANUFACTURING METHOD THEREOF AU OPTRONICS CORPORATION (TW) 2011-10-20 US claimed
EP-1813614-B1 Cytotoxic agents comprising new tomaymycin derivatives SANOFI SA (FR) 2011-10-05 EP claimed
US-20110002947-A1 LEPTOMYCIN DERIVATIVES SANOFI-AVENTIS (FR) 2011-01-06 US claimed
US-7514078-B2 Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies CORNELL RESEARCH FOUNDATION, INC. (US) 2009-04-07 US claimed
US-20240238432-A1 METHOD FOR GLYCOPROTEIN MODIFICATION HONEYBEAR BIOSCIENCES INC. (TW) 2024-07-18 US disclosed
US-20240226312-A1 TREATMENT OF CANCER IN PATIENTS WITH SOLUBLE FR-ALPHA IMMUNOGEN, INC. (US) 2024-07-11 US disclosed
WO-2024145600-A1 METHOD FOR GLYCOPROTEIN MODIFICATION HONEYBEAR BIOSCIENCES INC. (TW) 2024-07-04 WO disclosed
US-20240197898-A1 SUBSTITUTED BENZO[5,6][1,4]DIAZEPINO[1,2-a]INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISORDERS IMMUNOGEN, INC. 2024-06-20 US disclosed
US-20240190956-A1 CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS IMMUNOGEN INC (US) 2024-06-13 US disclosed
WO-1998016257-A2 STABILIZED MICROPARTICLES AND THEIR USE AS ULTRASOUND CONTRAST AGENTS MOLECULAR BIOSYSTEMS, INC. (US) 1998-04-23 WO disclosed
EP-0425235-B1 Cytotoxic agents comprising maytansinoids and their therapeutic use IMMUNOGEN INC (US) 1996-09-25 EP disclosed
US-5416064-A Antitumor agents IMMUNOGEN, INC. (US) 1995-05-16 US disclosed
EP-0404783-A4 IMMUNOASSAYS USING MONOCLONAL ANTIBODIES DIRECTED AGAINST NATURAL BINDING PROTEINS 1991-01-23 EP disclosed
EP-0404783-A1 IMMUNOASSAYS USING MONOCLONAL ANTIBODIES DIRECTED AGAINST NATURAL BINDING PROTEINS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-01-02 EP disclosed
WO-1989007271-A1 IMMUNOASSAYS USING MONOCLONAL ANTIBODIES DIRECTED AGAINST NATURAL BINDING PROTEINS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-08-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240197898-A1 SUBSTITUTED BENZO[5,6][1,4]DIAZEPINO[1,2-a]INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISORDERS MKI67, GABBR1, GABBR2 SMN1; SMN2 3393/4885ALDH1A1 540/4885TSHR 879/4885
US-20240190956-A1 CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS PCNA, EPCAM, MKI67 SMN1; SMN2 1659/4885ALDH1A1 96/4885TSHR 3064/4885
US-20240238432-A1 METHOD FOR GLYCOPROTEIN MODIFICATION SIGLEC7, FUT5, FUT6 SMN1; SMN2 3681/4885ALDH1A1 549/4885TSHR 1046/4885
US-20240226312-A1 TREATMENT OF CANCER IN PATIENTS WITH SOLUBLE FR-ALPHA FOLR1, FOLR2, FRS2 SMN1; SMN2 2467/4885ALDH1A1 2452/4885TSHR 79/4885
US-20110002947-A1 LEPTOMYCIN DERIVATIVES CLSPN, CD47, HCLS1 SMN1; SMN2 949/4885ALDH1A1 3948/4885TSHR 2217/4885
US-20200190199-A1 ANTIBODY-DRUG CONJUGATES AND USES THEREOF EGFR, ERBB2, ERBB3 SMN1; SMN2 4751/4885ALDH1A1 3084/4885TSHR 1296/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.