SCHEMBL8990318

SCHEMBL8990318

CCOC(C=O)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.43
LMNA P02545 4/20 0.41
MAPT P10636 2/20 0.41
ALDH1A1 P00352 2/20 0.41
POLB P06746 1/20 0.41
HTT P42858 2/20 0.40
KMT2A Q03164 1/20 0.38
MMP8 P22894 1/20 0.38
PPARG P37231 1/20 0.37
PPARA Q07869 1/20 0.37
MDM4 O15151 1/20 0.36
MDM2 Q00987 1/20 0.36
CYP2D6 P10635 2/20 0.35
SCN1A P35498 2/20 0.35
SCN2A Q99250 2/20 0.35
SCN3A Q9NY46 2/20 0.35
TSHR P16473 2/20 0.35
CYP1A2 P05177 1/20 0.35
CHRM2 P08172 1/20 0.35
CHRM4 P08173 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8990321 0.85 HTT (0.41) LMNAMAPTALDH1A1POLBHTT
SCHEMBL7894831 0.82 LTA4H (0.41) L3MBTL1LMNAALDH1A1HTTTSHR
SCHEMBL17578917 0.82 L3MBTL1 (0.40) L3MBTL1LMNAMAPTALDH1A1POLB
SCHEMBL11434362 0.80 CASR (0.40) L3MBTL1LMNAMAPTALDH1A1POLB
SCHEMBL28065522 0.79 NPC1 (0.45) LMNAALDH1A1TSHRSMN1; SMN2
SCHEMBL28143684 0.79 NPC1 (0.45) LMNAALDH1A1TSHRSMN1; SMN2
SCHEMBL4707444 0.79 BCHE (0.31) L3MBTL1LMNAMAPTALDH1A1
SCHEMBL9025351 0.78 SLC1A3 (0.46) ALDH1A1HTTKMT2ACYP2D6TSHR
SCHEMBL8467072 0.78 SLC1A3 (0.46) ALDH1A1HTTKMT2ACYP2D6TSHR
SCHEMBL8699347 0.78 THRB (0.39) L3MBTL1MAPTALDH1A1HTTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023180161-A2 METHODS FOR MAKING FLOW CELL SURFACES ILLUMINA CAMBRIDGE LIMITED (GB) 2023-09-28 WO disclosed
US-20190292488-A1 PERFUME COMPOSITIONS PROCTER & GAMBLE (US) 2019-09-26 US disclosed
CN-109377846-A The production method of human anatomy internal organ sample 内蒙古科技大学包头医学院 2019-02-22 CN disclosed
WO-2012164085-A1 GLYCINE B ANTAGONISTS MERZ PHARMA GMBH & CO. KGAA (DE) 2012-12-06 WO disclosed
US-20090318492-A1 INDOLE COMPOUNDS HAVING C4-ACIDIC SUBSTITUENTS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS ILYPSA, INC. 2009-12-24 US disclosed
CN-101395150-A Phenethanolamine derivatives as beta2 adrenoreceptor agonists ASTRAZENECA AB (SE) 2009-03-25 CN disclosed
US-5500484-A FROM ALDEHYDE KURARAY CO., LTD. (JP) 1996-03-19 US disclosed
EP-0641757-A1 2-Aryl-1,3-propanediol and dioxane derivatives and their preparation KURARAY CO., LTD. (JP) 1995-03-08 EP disclosed
US-5045567-A Propanolamine derivatives having anti-diabetic effects HOFFMANN-LA ROCHE INC. (US) 1991-09-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090318492-A1 INDOLE COMPOUNDS HAVING C4-ACIDIC SUBSTITUENTS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS PLA2G4A, PLA2G1B, PLA2G4B L3MBTL1 1676/4885LMNA 1907/4885MAPT 4609/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.