Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 15/20 | 0.73 |
| ▸ | SLC6A5 | Q9Y345 | 9/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.52 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.52 |
| ▸ | TAOK3 | Q9H2K8 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2514848 | 0.85 | HPGDS (0.57) | SLC6A9SLC6A5 | |
| SCHEMBL2009614 | 0.85 | SLC6A9 (1.00) | SLC6A9SLC6A5CYP2D6CYP2C9GPR139 | |
| SCHEMBL2007002 | 0.85 | SLC6A9 (0.88) | SLC6A9SLC6A5CYP2D6CYP2C9GPR139 | |
| SCHEMBL2011802 | 0.85 | SLC6A9 (0.88) | SLC6A9SLC6A5CYP2D6CYP2C9GPR139 | |
| SCHEMBL2514849 | 0.81 | LMNA (0.56) | SLC6A9 | |
| SCHEMBL15985718 | 0.80 | SMN1; SMN2 (0.50) | SLC6A9 | |
| SCHEMBL2008899 | 0.78 | SLC6A9 (0.88) | SLC6A9SLC6A5CYP2D6CYP2C9GPR139 | |
| SCHEMBL12572421 | 0.78 | SLC6A9 (1.00) | SLC6A9SLC6A5CYP2D6CYP2C9GPR139 | |
| SCHEMBL2009331 | 0.78 | SLC6A9 (1.00) | SLC6A9SLC6A5CYP2D6CYP2C9GPR139 | |
| SCHEMBL2009334 | 0.78 | SLC6A9 (1.00) | SLC6A9SLC6A5CYP2D6CYP2C9GPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150315243-A1 | METHODS FOR THE SYNTHESIS OF DICARBA BRIDGES IN ORGANIC COMPOUNDS | SYNGENE LTD (AU) | 2015-11-05 | — | — | US | disclosed |
| US-20150315243-A1 | METHODS FOR THE SYNTHESIS OF DICARBA BRIDGES IN ORGANIC COMPOUNDS | SYNGENE LTD (AU) | 2015-11-05 | — | — | US | disclosed |
| US-9102708-B2 | Methods for the synthesis of dicarba bridges in organic compounds | SYNGENE LIMITED (AU) | 2015-08-11 | — | — | US | disclosed |
| US-8759480-B2 | Contoxin analogues and methods for synthesis of intramolecular dicarba bridge-containing peptides | SYNGENE LIMITED (AU) | 2014-06-24 | — | — | US | disclosed |
| US-20130123463-A1 | METHODS FOR THE SYNTHESIS OF TWO OR MORE DICARBA BRIDGES IN ORGANIC COMPOUNDS | SYNGENE LIMITED (AU) | 2013-05-16 | — | — | US | disclosed |
| US-20130123463-A1 | METHODS FOR THE SYNTHESIS OF TWO OR MORE DICARBA BRIDGES IN ORGANIC COMPOUNDS | SYNGENE LIMITED (AU) | 2013-05-16 | — | — | US | disclosed |
| US-8362204-B2 | Methods for the synthesis of two or more dicarba bridges in organic compounds | SYNGENE LIMITED (AU) | 2013-01-29 | — | — | US | disclosed |
| US-20130023645-A1 | METHODS FOR THE SYNTHESIS OF DICARBA BRIDGES IN ORGANIC COMPOUNDS | SYNGENE LIMITED (AU) | 2013-01-24 | — | — | US | disclosed |
| US-20120142892-A1 | CONTOXIN ANALOGUES AND METHODS FOR SYNTHESIS OF INTRAMOLECULAR DICARBA BRIDGE-CONTAINING PEPTIDES | POLYCHIP PHARMACEUTICALS PTY LTD. (AU) | 2012-06-07 | — | — | US | disclosed |
| US-8188217-B2 | — | — | 2012-05-29 | — | — | US | disclosed |
| US-8124726-B2 | Contoxin analogues and methods for synthesizing same | MONASH UNIVERSITY (AU) | 2012-02-28 | — | — | US | disclosed |
| US-7745573-B2 | Conotoxin analogues and methods for synthesis of intramolecular dicarba bridge-containing peptides | POLYCHIP PHARMACEUTICALS PTY LTD. (AU) | 2010-06-29 | — | — | US | disclosed |
| US-20100036089-A1 | Methods for the Synthesis of Dicarba Bridges in Organic Compounds | MONASH UNIVERSITY (AU) | 2010-02-11 | — | — | US | disclosed |
| US-20100022749-A1 | Contoxin Analogues and Methods for Synthesizing Same | MONASH UNIVERSITY (AU) | 2010-01-28 | — | — | US | disclosed |
| US-7538190-B2 | Methods for the synthesis of two or more dicarba bridges in organic compounds | POLYCHIP PHARMACEUTICALS PTY LTD (AU) | 2009-05-26 | — | — | US | disclosed |
| US-20070197771-A1 | Methods for the synthesis of two or more dicarba bridges in organic compounds | SYNGENE LIMITED (AU) | 2007-08-23 | — | — | US | disclosed |
| US-20070197429-A1 | Conotoxin analogues and methods for synthesis of intramolecular dicarba bridge-containing peptides | SYNGENE LIMITED (AU) | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023645-A1 | METHODS FOR THE SYNTHESIS OF DICARBA BRIDGES IN ORGANIC COMPOUNDS | DCLRE1A, RNF168, CDCA2 | SLC6A9 2436/4885SLC6A5 2477/4885CYP2D6 1482/4885 |
| US-20130123463-A1 | METHODS FOR THE SYNTHESIS OF TWO OR MORE DICARBA BRIDGES IN ORGANIC COMPOUNDS | OTC, NBAS, IDH2 | SLC6A9 1489/4885SLC6A5 1613/4885CYP2D6 985/4885 |
| US-20120142892-A1 | CONTOXIN ANALOGUES AND METHODS FOR SYNTHESIS OF INTRAMOLECULAR DICARBA BRIDGE-CONTAINING PEPTIDES | VIP, CANX, INHA | SLC6A9 1714/4885SLC6A5 1517/4885CYP2D6 4374/4885 |
| US-20100022749-A1 | Contoxin Analogues and Methods for Synthesizing Same | VIP, CANX, PDIA5 | SLC6A9 2209/4885SLC6A5 2001/4885CYP2D6 4271/4885 |
| US-20100036089-A1 | Methods for the Synthesis of Dicarba Bridges in Organic Compounds | DCLRE1A, RNF168, MTCL3 | SLC6A9 2473/4885SLC6A5 2506/4885CYP2D6 1391/4885 |
| US-20150315243-A1 | METHODS FOR THE SYNTHESIS OF DICARBA BRIDGES IN ORGANIC COMPOUNDS | DCLRE1A, RNF168, MTCL3 | SLC6A9 2473/4885SLC6A5 2506/4885CYP2D6 1391/4885 |
| US-20070197771-A1 | Methods for the synthesis of two or more dicarba bridges in organic compounds | OTC, NBAS, IDH2 | SLC6A9 1489/4885SLC6A5 1613/4885CYP2D6 985/4885 |
| US-20070197429-A1 | Conotoxin analogues and methods for synthesis of intramolecular dicarba bridge-containing peptides | VIP, NRDC, INHA | SLC6A9 1584/4885SLC6A5 1418/4885CYP2D6 4780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.