Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8991244 | 0.90 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL8991207 | 0.89 | AURKA (0.40) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL8991272 | 0.88 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL8991378 | 0.87 | ADORA2A (0.41) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL8991419 | 0.86 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DEGFR | |
| SCHEMBL7696372 | 0.84 | ADORA2A (0.48) | HTTEGFRSRCNOTUMALDH1A1 | |
| SCHEMBL8991397 | 0.81 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL7700322 | 0.79 | ADK (0.33) | PDE4APDE4BPDE4CPDE4DEGFR | |
| SCHEMBL8991388 | 0.79 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL8991103 | 0.79 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5543413-A | VIRAL ACTIVITY AGAINST HUMAN CYTOMEGALOVIRUS AND HERPES SIMPLEX VIRUS | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1996-08-06 | — | — | US | disclosed |