Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8991110 | 0.90 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL8991272 | 0.89 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL8991207 | 0.88 | AURKA (0.40) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL7698505 | 0.86 | FYN (0.39) | TP53MAPTSLC29A1ALDH1A1KDM4E | |
| SCHEMBL8991419 | 0.83 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL8991078 | 0.81 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL8991063 | 0.79 | GAA (0.41) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL8991231 | 0.79 | GAA (0.41) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL8991147 | 0.79 | GAA (0.39) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL7700322 | 0.78 | ADK (0.33) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5543413-A | VIRAL ACTIVITY AGAINST HUMAN CYTOMEGALOVIRUS AND HERPES SIMPLEX VIRUS | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1996-08-06 | — | — | US | disclosed |