Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 14/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8991178 | 0.88 | RET (0.31) | RETMETFLT3KDR | |
| SCHEMBL8991135 | 0.87 | KDM4E (0.35) | RETFLT3RPS6KA3KDRKDM4E | |
| SCHEMBL8990968 | 0.81 | KDM4E (0.42) | RETKDRKDM4ETSHRMAPK1 | |
| SCHEMBL7703321 | 0.80 | RET (0.38) | RETENPP1RPS6KA3 | |
| SCHEMBL8991118 | 0.78 | RET (0.38) | RETENPP1 | |
| SCHEMBL7703318 | 0.78 | RET (0.39) | RETKDR | |
| SCHEMBL8991287 | 0.78 | FLT3 (0.40) | RETENPP1FLT3 | |
| SCHEMBL8991284 | 0.76 | KDM4E (0.44) | RETKDRKDM4ETSHRMAPK1 | |
| SCHEMBL8991176 | 0.76 | XDH (0.31) | — | |
| SCHEMBL8991058 | 0.74 | MAPK1 (0.55) | KDRKDM4ETSHRMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5543413-A | VIRAL ACTIVITY AGAINST HUMAN CYTOMEGALOVIRUS AND HERPES SIMPLEX VIRUS | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1996-08-06 | — | — | US | disclosed |