Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 8/20 | 0.51 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.51 |
| ▸ | HTR2A known ✓ | P28223 | 10/20 | 0.49 |
| ▸ | KCNH2 known ✓ | Q12809 | 7/20 | 0.48 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.47 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.47 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.47 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.47 |
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.47 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.47 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.47 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.47 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.47 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.47 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.47 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 6/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8991884 | 1.00 | DRD2 (0.51) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| SCHEMBL8918706 | 0.93 | DRD2 (0.56) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| SCHEMBL8918089 | 0.91 | DRD2 (0.54) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| SCHEMBL8920271 | 0.91 | DRD2 (0.56) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| SCHEMBL8916632 | 0.86 | DRD2 (0.54) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| SCHEMBL8918155 | 0.86 | DRD2 (0.53) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| SCHEMBL8917237 | 0.86 | DRD2 (0.53) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| SCHEMBL8916147 | 0.86 | DRD2 (0.54) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| SCHEMBL8917101 | 0.85 | DRD2 (0.54) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| Oxalic Acid SCHEMBL8917876 | 0.83 | HTR2A (0.51) | DRD2SLC6A4HTR2AHTR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5532240-A | ANTIPSYCHOTIC AGENTS AND ANTISEROTONIN AGENTS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1996-07-02 | — | — | US | disclosed |