SCHEMBL8992275

SCHEMBL8992275

CC(C)(C)NC1C=CC(c2ccccc2)(c2ccccc2)C1

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAOB P27338 6/20 0.32
MAOA P21397 3/20 0.32
HTR2A P28223 1/20 0.31
HTR2C P28335 1/20 0.31
HTR2B P41595 1/20 0.31
GRIN2D O15399 1/20 0.31
GRIN3B O60391 1/20 0.31
CHRM2 P08172 1/20 0.31
CHRM1 P11229 1/20 0.31
OPRM1 P35372 1/20 0.31
GRIN1 Q05586 1/20 0.31
KCNH2 Q12809 1/20 0.31
GRIN2A Q12879 1/20 0.31
GRIN2B Q13224 1/20 0.31
GRIN2C Q14957 1/20 0.31
GRIN3A Q8TCU5 1/20 0.31
DPP4 P27487 1/20 0.30
SLC6A4 P31645 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8992323 0.98 MAOB (0.33) MAOBMAOAHTR2AHTR2CHTR2B
SCHEMBL8992324 0.91 ATM (0.32) MAOB
Hydrochloric Acid SCHEMBL8992580 0.79 HTR2A (0.39) MAOBMAOAHTR2AHTR2CHTR2B
SCHEMBL8992408 0.78 ALDH1A1 (0.33)
SCHEMBL9586923 0.77 HSD11B1 (0.34)
SCHEMBL8992411 0.77 ATM (0.34)
SCHEMBL8992256 0.77 GAA (0.34) MAOBMAOAHTR2AHTR2CHTR2B
Hydrochloric Acid SCHEMBL8992342 0.76 LMNA (0.37) MAOBMAOAOPRM1
Hydrochloric Acid SCHEMBL8992591 0.75 HTR2A (0.36) MAOBMAOAHTR2AHTR2CHTR2B
SCHEMBL8992435 0.74 MEN1 (0.41) HTR2BCHRM2CHRM1OPRM1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0445749-B1 N-Monosubstituted cyclopentenylamines, a process for their preparation and their use as medicaments FUJISAWA PHARMACEUTICAL CO (JP) 1996-07-10 EP claimed
US-5256824-A Anticholinergic agents FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-10-26 US claimed
EP-0445749-A1 N-Monosubstituted cyclopentenylamines, a process for their preparation and their use as medicaments FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1991-09-11 EP claimed
JP-4234832-A None JP disclosed
EP-0445749-B1 N-Monosubstituted cyclopentenylamines, a process for their preparation and their use as medicaments FUJISAWA PHARMACEUTICAL CO (JP) 1996-07-10 EP disclosed
US-5256824-A Anticholinergic agents FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-10-26 US disclosed
US-5256824-A Anticholinergic agents FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-10-26 US disclosed
JP-H04234832-A NEW SUBSTITUTED AMINE COMPOUND AND ITS PRODUCTION FUJISAWA PHARMACEUT CO LTD 1992-08-24 JP disclosed
EP-0445749-A1 N-Monosubstituted cyclopentenylamines, a process for their preparation and their use as medicaments FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1991-09-11 EP disclosed