Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3571617 | 0.81 | ALDH1A1 (0.47) | ALDH1A1PPARGPPARDSMN1; SMN2 | |
| SCHEMBL8021420 | 0.79 | ALDH1A1 (0.38) | BRD4CREBBPNPC1RAB9AALDH1A1 | |
| SCHEMBL2200862 | 0.75 | ALDH1A1 (0.48) | NPC1RAB9AALDH1A1FGFR1FGFR2 | |
| SCHEMBL4723773 | 0.75 | MAOA (0.48) | NPC1RAB9AMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL1818480 | 0.75 | ALDH1A1 (0.58) | BRD4CREBBPALDH1A1CYP3A4KMT2A | |
| SCHEMBL3569410 | 0.74 | MAPK1 (0.47) | BRD4ALDH1A1 | |
| SCHEMBL19903859 | 0.74 | RAB9A (0.36) | NPC1RAB9AALDH1A1ALOX5PTPN1 | |
| SCHEMBL3543214 | 0.74 | ABL1 (0.55) | BRD4CREBBPNPC1RAB9AALDH1A1 | |
| SCHEMBL9222651 | 0.73 | NPC1 (0.30) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5730369 | 0.73 | TUBB4A (0.31) | NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516777-A | PROSTATE CANCER THERAPY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-14 | — | — | US | disclosed |
| US-5409928-A | Prostate diseases, alopecia | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0594149-A2 | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |