Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.57 |
| ▸ | DHFR | P00374 | 1/20 | 0.48 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | AGXT | P21549 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | BRS3 | P32247 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8993074 | 0.84 | DHFR (0.49) | LTA4HDHFRHTR1BTAAR1IDO1 | |
| SCHEMBL8992949 | 0.84 | DHFR (0.49) | LTA4HDHFRHTR1BTAAR1IDO1 | |
| SCHEMBL8992834 | 0.84 | LTA4H (0.53) | LTA4HTAAR1IDO1BRS3 | |
| SCHEMBL8993116 | 0.81 | LTA4H (0.45) | LTA4HLTB4RFGFR1 | |
| SCHEMBL4700185 | 0.80 | TDO2 (0.55) | ADORA1 | |
| SCHEMBL8136072 | 0.77 | TAAR1 (0.61) | LTA4HDHFRTAAR1IDO1AGXT | |
| SCHEMBL27289916 | 0.76 | LTA4H (0.60) | LTA4HHTR1BTAAR1IDO1AGXT | |
| SCHEMBL29415515 | 0.75 | LTA4H (0.49) | LTA4HDHFRLTB4RHTR1BTAAR1 | |
| SCHEMBL28717354 | 0.75 | LTA4H (0.49) | LTA4HDHFRLTB4RHTR1BTAAR1 | |
| SCHEMBL14191204 | 0.75 | LTA4H (0.70) | LTA4HHTR1BTAAR1IDO1AGXT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516777-A | PROSTATE CANCER THERAPY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-14 | — | — | US | disclosed |
| US-5409928-A | Prostate diseases, alopecia | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0594149-A2 | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |