Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | RGS4 | P49798 | 1/20 | 0.40 |
| ▸ | RGS8 | P57771 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL899306 | 1.00 | MAPT (0.46) | MAPTSMN1; SMN2HTTLMNAMAPK1 | |
| SCHEMBL899437 | 0.87 | PDE4D (0.39) | MAPTSMN1; SMN2HTTLMNAMAPK1 | |
| SCHEMBL899436 | 0.87 | PDE4D (0.39) | MAPTSMN1; SMN2HTTLMNAMAPK1 | |
| SCHEMBL899584 | 0.84 | SMN1; SMN2 (0.42) | MAPTSMN1; SMN2LMNAMAPK1ALDH1A1 | |
| SCHEMBL899582 | 0.84 | SMN1; SMN2 (0.42) | MAPTSMN1; SMN2LMNAMAPK1ALDH1A1 | |
| SCHEMBL10045111 | 0.81 | PDE7A (0.36) | MAPTSMN1; SMN2MAPK1ALDH1A1NPC1 | |
| SCHEMBL899218 | 0.76 | PDE4D (0.38) | MAPTSMN1; SMN2HTTMAPK1ALDH1A1 | |
| SCHEMBL903016 | 0.74 | ALDH1A1 (0.40) | MAPTSMN1; SMN2HTTLMNAMAPK1 | |
| SCHEMBL28179465 | 0.69 | CYP11B1 (0.56) | MAPTSMN1; SMN2HTTLMNAALDH1A1 | |
| SCHEMBL5445050 | 0.67 | HRH3 (0.55) | MAPTLMNAMAPK1ALDH1A1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012040754-A2 | NOVEL THIAZOLAMINE DERIVATES AS DIFFERENTIATION ACCELERATORS | TECHNISCHE UNIVERSITÄT WIEN (AT) | 2012-04-05 | — | — | WO | claimed |
| WO-2012040754-A2 | NOVEL THIAZOLAMINE DERIVATES AS DIFFERENTIATION ACCELERATORS | TECHNISCHE UNIVERSITÄT WIEN (AT) | 2012-04-05 | — | — | WO | disclosed |