Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL899436 | 1.00 | PDE4D (0.39) | PDE4DPDE7ACYP19A1IDO1CYP11B1 | |
| SCHEMBL899582 | 0.90 | SMN1; SMN2 (0.42) | PDE4DPDE7ACYP11B1CYP11B2SMN1; SMN2 | |
| SCHEMBL899584 | 0.90 | SMN1; SMN2 (0.42) | PDE4DPDE7ACYP11B1CYP11B2SMN1; SMN2 | |
| SCHEMBL899307 | 0.87 | MAPT (0.46) | CYP11B1CYP11B2SMN1; SMN2LMNAMAPT | |
| SCHEMBL899306 | 0.87 | MAPT (0.46) | CYP11B1CYP11B2SMN1; SMN2LMNAMAPT | |
| SCHEMBL899463 | 0.85 | LMNA (0.43) | SMN1; SMN2LMNAGAAMAPK1KDM4E | |
| SCHEMBL10045111 | 0.83 | PDE7A (0.36) | PDE4DPDE7ASMN1; SMN2GAAMAPT | |
| SCHEMBL903016 | 0.83 | ALDH1A1 (0.40) | SMN1; SMN2LMNAGAAMAPTMAPK1 | |
| SCHEMBL898781 | 0.81 | ROCK2 (0.41) | PDE4DPDE7ASMN1; SMN2LMNAMAPK1 | |
| SCHEMBL898780 | 0.81 | ROCK2 (0.41) | PDE4DPDE7ASMN1; SMN2LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012040754-A2 | NOVEL THIAZOLAMINE DERIVATES AS DIFFERENTIATION ACCELERATORS | TECHNISCHE UNIVERSITÄT WIEN (AT) | 2012-04-05 | — | — | WO | claimed |
| WO-2012040754-A2 | NOVEL THIAZOLAMINE DERIVATES AS DIFFERENTIATION ACCELERATORS | TECHNISCHE UNIVERSITÄT WIEN (AT) | 2012-04-05 | — | — | WO | disclosed |