Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL899584 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAPOLBNPSR1MAPK1 | |
| SCHEMBL899436 | 0.90 | PDE4D (0.39) | SMN1; SMN2LMNANPSR1MAPK1PDE7A | |
| SCHEMBL899437 | 0.90 | PDE4D (0.39) | SMN1; SMN2LMNANPSR1MAPK1PDE7A | |
| SCHEMBL899307 | 0.84 | MAPT (0.46) | SMN1; SMN2LMNANPSR1MAPK1CYP11B1 | |
| SCHEMBL899306 | 0.84 | MAPT (0.46) | SMN1; SMN2LMNANPSR1MAPK1CYP11B1 | |
| SCHEMBL898781 | 0.81 | ROCK2 (0.41) | SMN1; SMN2LMNAPOLBNPSR1MAPK1 | |
| SCHEMBL10045111 | 0.80 | PDE7A (0.36) | SMN1; SMN2NPSR1MAPK1PDE7APDE1A | |
| SCHEMBL903016 | 0.77 | ALDH1A1 (0.40) | SMN1; SMN2LMNANPSR1MAPK1PTGS2 | |
| SCHEMBL898806 | 0.77 | GRM5 (0.34) | SMN1; SMN2NPSR1MAPK1PDE7APDE4D | |
| SCHEMBL898805 | 0.77 | GRM5 (0.34) | SMN1; SMN2NPSR1MAPK1PDE7APDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012040754-A2 | NOVEL THIAZOLAMINE DERIVATES AS DIFFERENTIATION ACCELERATORS | TECHNISCHE UNIVERSITÄT WIEN (AT) | 2012-04-05 | — | — | WO | claimed |
| WO-2012040754-A2 | NOVEL THIAZOLAMINE DERIVATES AS DIFFERENTIATION ACCELERATORS | TECHNISCHE UNIVERSITÄT WIEN (AT) | 2012-04-05 | — | — | WO | disclosed |
| WO-2012040754-A2 | NOVEL THIAZOLAMINE DERIVATES AS DIFFERENTIATION ACCELERATORS | TECHNISCHE UNIVERSITÄT WIEN (AT) | 2012-04-05 | — | — | WO | disclosed |