SCHEMBL8993430

SCHEMBL8993430

CCc1cc(Oc2ncc(Cl)cn2)cc(C(=O)O)c1[N+](=O)[O-]

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PKM P14618 1/20 0.37
GABRP O00591 1/20 0.35
GABRD O14764 1/20 0.35
GABRA1 P14867 1/20 0.35
GABRB1 P18505 1/20 0.35
GABRG2 P18507 1/20 0.35
GABRB3 P28472 1/20 0.35
GABRA5 P31644 1/20 0.35
GABRA3 P34903 1/20 0.35
GABRA2 P47869 1/20 0.35
GABRB2 P47870 1/20 0.35
GABRA4 P48169 1/20 0.35
GABRE P78334 1/20 0.35
GABRA6 Q16445 1/20 0.35
GABRG1 Q8N1C3 1/20 0.35
GABRG3 Q99928 1/20 0.35
GABRQ Q9UN88 1/20 0.35
CYP1A2 P05177 2/20 0.33
CYP2D6 P10635 2/20 0.33
CYP2C19 P33261 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9852601 0.78 TDP1 (0.54) ALDH1A1TDP1MEN1KMT2ATTR
SCHEMBL10661895 0.77 ALDH1A1 (0.47) PKMCYP1A2CYP2D6CYP2C19ALDH1A1
SCHEMBL9788466 0.72 TDP1 (0.66) TDP1MEN1KMT2ATTRPPOX
SCHEMBL8993428 0.70 TDP1 (0.50) PKMCYP1A2CYP2C19ALDH1A1TDP1
SCHEMBL29141466 0.67 PKM (0.43) PKMCYP1A2CYP2D6CYP2C19ALDH1A1
SCHEMBL27622980 0.66 HTT (0.46) PKMGABRPGABRDGABRA1GABRB1
SCHEMBL8993544 0.65 MRGPRX4 (0.44) CYP1A2CYP2D6CYP2C19ALDH1A1MEN1
SCHEMBL11088590 0.65 MAPT (0.46) ALDH1A1TDP1MEN1KMT2AMAPT
SCHEMBL11315353 0.64 PLA2G2A (0.57) TP53
SCHEMBL11082969 0.64 ALDH1A1 (0.45) CYP1A2ALDH1A1TDP1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0315889-B1 Pyrimidine derivatives, processes for their production, and herbicidal method and compositions KUMIAI CHEMICAL INDUSTRY CO (JP) 1996-07-17 EP disclosed
US-4923501-A COTTON; NONPHYTOTOXIC KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1990-05-08 US disclosed
EP-0315889-A2 Pyrimidine derivatives, processes for their production, and herbicidal method and compositions KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1989-05-17 EP disclosed