Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.30 |
| ▸ | S100A9 | P06702 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8993449 | 0.80 | PTGS2 (0.45) | PTGS2PDGFRBPDGFRAPTGS1S100A9 | |
| SCHEMBL8993514 | 0.76 | PTGS2 (0.52) | PTGS2 | |
| SCHEMBL8993563 | 0.70 | PTGS2 (0.35) | PTGS2 | |
| SCHEMBL8993495 | 0.67 | PIM1 (0.37) | PIM1TRPV1 | |
| SCHEMBL8993599 | 0.65 | PTGS2 (0.49) | PTGS2PTGS1 | |
| SCHEMBL8993497 | 0.62 | CSF1R (0.31) | — | |
| SCHEMBL17196425 | 0.60 | HRH4 (0.36) | PTGS2PTGS1S100A9 | |
| SCHEMBL17177764 | 0.60 | HRH4 (0.39) | PTGS2PTGS1S100A9 | |
| SCHEMBL16835995 | 0.60 | TRPV1 (0.40) | TRPV1 | |
| SCHEMBL4432809 | 0.59 | LMNA (0.50) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724566-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995011883-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-05-04 | — | — | WO | disclosed |