Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 3/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | S100A9 | P06702 | 1/20 | 0.30 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.30 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8993451 | 0.80 | PTGS2 (0.39) | PTGS2PDGFRBPDGFRAS100A9PTGS1 | |
| SCHEMBL8993514 | 0.74 | PTGS2 (0.52) | PTGS2GRM2PTGDR2 | |
| SCHEMBL8993563 | 0.68 | PTGS2 (0.35) | PTGS2 | |
| SCHEMBL6239385 | 0.67 | PTGS2 (0.60) | PTGS2PTGS1 | |
| SCHEMBL6239381 | 0.67 | PTGS2 (0.60) | PTGS2PTGS1 | |
| SCHEMBL8993493 | 0.66 | ALDH1A1 (0.46) | PTGS2GRM2CCNE1CDK2 | |
| SCHEMBL17202468 | 0.66 | PTGS2 (0.46) | PTGS2RAB9A | |
| SCHEMBL4432809 | 0.66 | LMNA (0.50) | PTGS2GRM2RAB9A | |
| SCHEMBL8993599 | 0.66 | PTGS2 (0.49) | PTGS2PTGS1 | |
| SCHEMBL8993654 | 0.64 | F2RL1 (0.36) | PSMB5GRM2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724566-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995011883-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-05-04 | — | — | WO | disclosed |