Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL1 | P55085 | 2/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | ACACB | O00763 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8993493 | 0.81 | ALDH1A1 (0.46) | F2RL1GRM2KDRCCNE1CDK2 | |
| SCHEMBL8993437 | 0.67 | F2RL1 (0.40) | F2RL1GRM2KDRCCNE1CDK2 | |
| SCHEMBL8595993 | 0.65 | KDM4E (0.40) | ALDH1A1L3MBTL1 | |
| SCHEMBL8993449 | 0.64 | PTGS2 (0.45) | GRM2CCNE1CDK2PSMB5 | |
| SCHEMBL24322146 | 0.64 | KDR (0.35) | F2RL1GRM2KDRCCNE1CDK2 | |
| SCHEMBL8993495 | 0.64 | PIM1 (0.37) | F2RL1GRM2ALDH1A1L3MBTL1 | |
| SCHEMBL29118646 | 0.64 | ALDH1A1 (0.33) | ALDH1A1L3MBTL1 | |
| SCHEMBL23857046 | 0.63 | NOS2 (0.44) | ALDH1A1L3MBTL1 | |
| SCHEMBL24322334 | 0.62 | AXL (0.34) | F2RL1GRM2KDRCCNE1CDK2 | |
| SCHEMBL22920105 | 0.62 | LNPEP (0.51) | KDRPSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724566-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-07 | — | — | EP | claimed |
| WO-1995011883-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-05-04 | — | — | WO | claimed |