Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.50 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 4/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8653103 | 0.85 | PTGS2 (0.58) | PTGS2PTGER1 | |
| SCHEMBL21769972 | 0.83 | MKNK1 (0.43) | PTGS2PDCD1CD274IDO1MKNK1 | |
| SCHEMBL8654013 | 0.71 | PTGS2 (0.62) | PTGS2PTGER1 | |
| SCHEMBL29899606 | 0.70 | ENPP2 (0.45) | — | |
| SCHEMBL95655 | 0.70 | ENPP2 (0.45) | — | |
| SCHEMBL27587389 | 0.69 | PTGS2 (0.55) | PTGS2PTGER1 | |
| SCHEMBL21363123 | 0.68 | BCL2 (0.44) | PTGS2IDO1 | |
| SCHEMBL8993500 | 0.68 | PTGS2 (0.74) | PTGS2 | |
| SCHEMBL8655486 | 0.67 | PTGS2 (1.00) | PTGS2 | |
| SCHEMBL564610 | 0.66 | SLC6A4 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724566-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995011883-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-05-04 | — | — | WO | disclosed |