Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 2/20 | 0.45 |
| ▸ | ACE | P12821 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328756 | 0.88 | F2 (0.50) | CYP3A4CYP2C9PKMCYP2C19F2 | |
| SCHEMBL9569401 | 0.88 | F2 (0.50) | CYP3A4CYP2C9PKMCYP2C19F2 | |
| SCHEMBL8994560 | 0.83 | ACE (0.46) | PKMACELMNAALDH1A1NPC1 | |
| SCHEMBL8994559 | 0.83 | ACE (0.46) | PKMACELMNAALDH1A1NPC1 | |
| SCHEMBL7265280 | 0.76 | F2 (0.53) | CYP3A4CYP2C9PKMCYP2C19F2 | |
| SCHEMBL8633510 | 0.76 | F2 (0.53) | CYP3A4CYP2C9PKMCYP2C19F2 | |
| SCHEMBL9569339 | 0.76 | F2 (0.56) | CYP3A4CYP2C9PKMCYP2C19F2 | |
| SCHEMBL7282828 | 0.76 | F2 (0.56) | CYP3A4CYP2C9PKMCYP2C19F2 | |
| SCHEMBL9873989 | 0.74 | ALDH1A1 (0.50) | CYP3A4ACELMNAALDH1A1 | |
| SCHEMBL12300145 | 0.72 | SMN1; SMN2 (0.71) | F2ALDH1A1USP2HPGDSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545657-A | 1-ALKYLOYLPYRROLIDIN-2-YLOXOALKANOIC ACIDS AND DERIVATIVES; ANTIAMNESIA AGENTS; INHIBITORS OF PROLYL ENDOPEPTIDASE; SUPPRESSION OF NEUROTRANSMITTER METABOLISM | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-13 | — | — | US | disclosed |
| US-5212191-A | Thiazoline derivatives for treatment of amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-05-18 | — | — | US | disclosed |
| US-5053414-A | Thiazolidine derivatives, enzyme inhibitors; amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-01 | — | — | US | disclosed |