Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8994560 | 1.00 | ACE (0.46) | ACELMNAALDH1A1SMN1; SMN2PREP | |
| SCHEMBL9569386 | 0.88 | SLC6A1 (0.41) | ACESMN1; SMN2PREPPOLBMEN1 | |
| SCHEMBL7290559 | 0.88 | SLC6A1 (0.41) | ACESMN1; SMN2PREPPOLBMEN1 | |
| SCHEMBL8994630 | 0.83 | CYP3A4 (0.47) | ACELMNAALDH1A1PREPPKM | |
| SCHEMBL9255056 | 0.76 | ACE (0.46) | ACESMN1; SMN2 | |
| SCHEMBL9569393 | 0.76 | ACE (0.46) | ACESMN1; SMN2 | |
| SCHEMBL7325890 | 0.76 | PREP (0.44) | SMN1; SMN2PREPPOLBMEN1NPC1 | |
| SCHEMBL7325895 | 0.76 | PREP (0.44) | SMN1; SMN2PREPPOLBMEN1NPC1 | |
| SCHEMBL9873989 | 0.75 | ALDH1A1 (0.50) | ACELMNAALDH1A1L3MBTL1 | |
| SCHEMBL7324911 | 0.73 | PREP (0.44) | SMN1; SMN2PREPPOLBMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545657-A | 1-ALKYLOYLPYRROLIDIN-2-YLOXOALKANOIC ACIDS AND DERIVATIVES; ANTIAMNESIA AGENTS; INHIBITORS OF PROLYL ENDOPEPTIDASE; SUPPRESSION OF NEUROTRANSMITTER METABOLISM | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-13 | — | — | US | disclosed |
| US-5401760-A | Thiazoline derivative for treating amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-03-28 | — | — | US | disclosed |
| US-5212191-A | Thiazoline derivatives for treatment of amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-05-18 | — | — | US | disclosed |
| US-5053414-A | Thiazolidine derivatives, enzyme inhibitors; amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-01 | — | — | US | disclosed |