Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.49 |
| ▸ | PPARD | Q03181 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8994937 | 0.90 | PLA2G4B (0.64) | PLA2G4BMAPTALDH1A1LTB4RPRSS1 | |
| SCHEMBL8995020 | 0.88 | PLA2G4B (0.53) | PLA2G4BMAPTALDH1A1LTB4RPRSS1 | |
| SCHEMBL8748091 | 0.83 | LTB4R (0.74) | PLA2G4BMAPTALDH1A1LTB4RPRSS1 | |
| SCHEMBL8747939 | 0.83 | LTB4R (0.74) | PLA2G4BMAPTALDH1A1LTB4RPRSS1 | |
| SCHEMBL18707316 | 0.83 | MRGPRX4 (0.58) | MAPTALDH1A1KMT2AHPGDHDAC1 | |
| SCHEMBL8747942 | 0.82 | LTB4R (0.53) | PLA2G4BMAPTALDH1A1LTB4RMAOB | |
| SCHEMBL8748088 | 0.82 | LTB4R (0.72) | PLA2G4BMAPTALDH1A1LTB4RPRSS1 | |
| SCHEMBL9306797 | 0.81 | THRA (0.65) | PLA2G4BPRSS1THRATHRBTSHR | |
| SCHEMBL9578512 | 0.81 | THRA (0.65) | PLA2G4BPRSS1THRATHRBTSHR | |
| SCHEMBL11239964 | 0.81 | THRA (0.57) | PLA2G4BMAPTPRSS1THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0518819-B1 | Amidino compounds, their manufacture and use as medicament | CIBA GEIGY AG (CH) | 1995-08-02 | — | — | EP | disclosed |
| EP-0518819-A2 | Amidino compounds, their manufacture and use as medicament | CIBA-GEIGY AG (CH) | 1992-12-16 | — | — | EP | disclosed |