Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA6 | P23280 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | TPMT | P51580 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.53 |
| ▸ | PPARD | Q03181 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8994850 | 0.90 | PLA2G4B (0.53) | PLA2G4BMAPTTSHRALDH1A1HPGD | |
| SCHEMBL8995020 | 0.90 | PLA2G4B (0.53) | PLA2G4BMAPTALDH1A1LTB4RPPARD | |
| SCHEMBL6680243 | 0.89 | MMP2 (0.57) | PLA2G4BMAPTTSHRALDH1A1HPGD | |
| SCHEMBL6675503 | 0.89 | MMP2 (0.57) | PLA2G4BMAPTTSHRALDH1A1HPGD | |
| SCHEMBL8747939 | 0.85 | LTB4R (0.74) | PLA2G4BMAPTALDH1A1LTB4RPPARD | |
| SCHEMBL8748091 | 0.85 | LTB4R (0.74) | PLA2G4BMAPTALDH1A1LTB4RPPARD | |
| SCHEMBL21614005 | 0.85 | TSHR (0.76) | PLA2G4BMAPTTSHRCA12CA1 | |
| SCHEMBL8747942 | 0.84 | LTB4R (0.53) | PLA2G4BMAPTALDH1A1HPGDLTB4R | |
| SCHEMBL8748088 | 0.84 | LTB4R (0.72) | PLA2G4BMAPTALDH1A1LTB4RPPARD | |
| SCHEMBL8122418 | 0.84 | TSHR (0.78) | PLA2G4BMAPTTSHRCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0518819-B1 | Amidino compounds, their manufacture and use as medicament | CIBA GEIGY AG (CH) | 1995-08-02 | — | — | EP | disclosed |
| EP-0518819-A2 | Amidino compounds, their manufacture and use as medicament | CIBA-GEIGY AG (CH) | 1992-12-16 | — | — | EP | disclosed |