Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.49 |
| ▸ | PPARD | Q03181 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8994937 | 0.90 | PLA2G4B (0.64) | PLA2G4BMAPTALDH1A1LTB4RPRSS1 | |
| SCHEMBL8994850 | 0.88 | PLA2G4B (0.53) | PLA2G4BMAPTALDH1A1KMT2ALTB4R | |
| SCHEMBL5767014 | 0.86 | MAPT (0.64) | MAPTKMT2APRSS1MAOBMGLL | |
| SCHEMBL14539213 | 0.83 | L3MBTL4 (0.46) | PLA2G4BMAPTALDH1A1KMT2ALTB4R | |
| SCHEMBL8747939 | 0.83 | LTB4R (0.74) | PLA2G4BMAPTALDH1A1LTB4RPRSS1 | |
| SCHEMBL8748091 | 0.83 | LTB4R (0.74) | PLA2G4BMAPTALDH1A1LTB4RPRSS1 | |
| SCHEMBL13093599 | 0.83 | LTB4R (0.45) | PLA2G4BMAPTALDH1A1KMT2ALTB4R | |
| SCHEMBL8747942 | 0.82 | LTB4R (0.53) | PLA2G4BMAPTALDH1A1LTB4RMAOB | |
| SCHEMBL8748088 | 0.82 | LTB4R (0.72) | PLA2G4BMAPTALDH1A1LTB4RPRSS1 | |
| SCHEMBL2149738 | 0.82 | MAPT (0.66) | MAPTALDH1A1KMT2APRSS1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0518819-B1 | Amidino compounds, their manufacture and use as medicament | CIBA GEIGY AG (CH) | 1995-08-02 | — | — | EP | disclosed |
| EP-0518819-A2 | Amidino compounds, their manufacture and use as medicament | CIBA-GEIGY AG (CH) | 1992-12-16 | — | — | EP | disclosed |