Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29286607 | 0.73 | TAAR1 (0.50) | — | |
| SCHEMBL8995945 | 0.73 | MEN1 (0.45) | KMT2AMEN1MAPTDPP7KCNH2 | |
| SCHEMBL9129256 | 0.72 | KCNH2 (0.62) | MAPTKCNH2 | |
| SCHEMBL8995934 | 0.72 | HTT (0.44) | KMT2AMEN1L3MBTL1MAPTDPP7 | |
| SCHEMBL9129725 | 0.70 | TAAR1 (0.47) | MAPTDPP7KCNH2 | |
| SCHEMBL8987727 | 0.70 | KCNH2 (0.44) | L3MBTL1MAPTDPP7KCNH2ALDH1A1 | |
| SCHEMBL8987627 | 0.70 | CYP2C9 (0.47) | MAPTDPP7ALDH1A1HTTRAB9A | |
| SCHEMBL8987696 | 0.70 | HDAC3 (0.46) | TSHRMAPTDPP7ALDH1A1HTT | |
| SCHEMBL17181662 | 0.69 | IDO1 (0.52) | KMT2AMEN1MAPTALDH1A1RAB9A | |
| SCHEMBL8995931 | 0.69 | FDPS (0.43) | KMT2AMEN1DPP7KCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5538956-A | G-AMINOBUTYRIC ACID AUTORECEPTOR AGONISTS, ANTIDEPRESSANTS, TREATING SENILE DEMENTIA | JOHN WYETH & BROTHER, LIMITED (GB) | 1996-07-23 | — | — | US | disclosed |
| WO-1993011138-A1 | AMINE DERIVATIVES CONTAINING A PHOSPHONIC, PHOSPHONOUS OR PHOSPHINIC ACID MOIETY | JOHN WYETH & BROTHER LIMITED (GB) | 1993-06-10 | — | — | WO | disclosed |