Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.55 |
| ▸ | ATIC | P31939 | 2/20 | 0.53 |
| ▸ | GART | P22102 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9758306 | 1.00 | DHFR (0.55) | DHFRATICGART | |
| SCHEMBL9227822 | 0.97 | DHFR (0.52) | DHFRATICGART | |
| SCHEMBL8997253 | 0.90 | DHFR (0.58) | DHFRATICGART | |
| SCHEMBL9227834 | 0.90 | DHFR (0.45) | DHFRATICGART | |
| SCHEMBL9397716 | 0.89 | DHFR (0.53) | DHFRATICGART | |
| SCHEMBL8997146 | 0.88 | ATIC (0.50) | DHFRATICGART | |
| SCHEMBL8997214 | 0.88 | ATIC (0.49) | ATICGART | |
| SCHEMBL9758337 | 0.86 | DHFR (0.60) | DHFRATICGART | |
| SCHEMBL8997198 | 0.86 | ATIC (0.48) | DHFRATICGART | |
| SCHEMBL10808300 | 0.86 | GART (0.62) | DHFRATICGART |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997838-A | Antitumor agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-03-05 | — | — | US | claimed |
| CN-1051306-C | Production of pyrrolopyrimidines and intermadiates therefor | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-04-12 | — | — | CN | disclosed |
| EP-0334636-B1 | Pyrrolopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-10-23 | — | — | EP | disclosed |
| US-5539113-A | ANTITUMOR AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-07-23 | — | — | US | disclosed |
| CN-1032003-C | Process for preparing pyrrolopyrimidines | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-06-12 | — | — | CN | disclosed |
| US-5496946-A | Production of pyrrolopyrimidines and intermediates therefor | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| CN-1103401-A | Production of pyrrolopyrimidines and intermadiates therefor | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-06-07 | — | — | CN | disclosed |
| US-5349064-A | Production of pyrrolopyrimidines | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-09-20 | — | — | US | disclosed |
| US-5296600-A | Antitumor agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-22 | — | — | US | disclosed |
| US-5106974-A | Antitumor and -carcinogenic agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-04-21 | — | — | US | disclosed |
| US-4997838-A | Antitumor agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-03-05 | — | — | US | disclosed |
| CN-1048705-A | Process for preparing pyrrolopyrimidines and intermediates thereof | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1991-01-23 | — | — | CN | disclosed |
| EP-0402903-A1 | Production of pyrrolopyrimidines and intermediates therefor | Takeda Chemical Industries, Ltd. (JP) | 1990-12-19 | — | — | EP | disclosed |
| EP-0334636-A2 | Pyrrolopyrimidine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1989-09-27 | — | — | EP | disclosed |