Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 2/20 | 0.50 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.41 |
| ▸ | PTGFR | P43088 | 3/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.41 |
| ▸ | PTGIR | P43119 | 3/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.41 |
| ▸ | EDNRB | P24530 | 4/20 | 0.41 |
| ▸ | EDNRA | P25101 | 4/20 | 0.41 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8240985 | 0.82 | CASP1 (0.56) | CASP1PTGER1PTGER3PTGER2EDNRB | |
| SCHEMBL7023007 | 0.79 | CASP1 (0.54) | CASP1PTGER1PTGER3PTGER2EDNRB | |
| SCHEMBL5147607 | 0.79 | CASP1 (0.54) | CASP1EDNRBEDNRACA1CA2 | |
| SCHEMBL15924605 | 0.78 | CASP1 (0.47) | CASP1EDNRBEDNRAKAT6ATACR1 | |
| SCHEMBL2452804 | 0.77 | CASP1 (0.48) | CASP1EDNRBEDNRA | |
| SCHEMBL10916572 | 0.76 | CASP1 (0.51) | CASP1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL1767981 | 0.76 | CA2 (0.58) | CASP1EDNRBEDNRAHDAC8HDAC6 | |
| SCHEMBL29537027 | 0.76 | CA2 (0.58) | CASP1EDNRBEDNRAHDAC8HDAC6 | |
| SCHEMBL15668311 | 0.74 | CASP1 (0.51) | CASP1EDNRBEDNRABCL2BCL2L1 | |
| SCHEMBL9682375 | 0.74 | CASP1 (0.49) | CASP1EDNRBEDNRABCL2BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5512681-A | HORMONE INHIBITORS FOR TREATMENT OF HYPERTENSION OR CONGESTIVE HEART FAILURE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1996-04-30 | — | — | US | disclosed |