SCHEMBL8998

SCHEMBL8998

c1ccc(CC2CCCS2)cc1

nearest known ligand 0.46

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
FAAH O00519 1/20 0.43
POLB P06746 1/20 0.42
GBA1 P04062 1/20 0.41
NOS3 P29474 1/20 0.39
NOS1 P29475 1/20 0.39
NOS2 P35228 1/20 0.39
CCR3 P51677 1/20 0.38
ACE P12821 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28090 0.94 POLB (0.44) FAAHPOLBGBA1NOS3NOS1
SCHEMBL7262319 0.81 MAPT (0.38)
SCHEMBL7262222 0.77 ALDH1A1 (0.37)
SCHEMBL6760449 0.77 LMNA (0.41)
SCHEMBL5262180 0.77 TSHR (0.45) FAAHPOLB
SCHEMBL6916462 0.76 GBA1 (0.43) POLBGBA1CCR3ACE
SCHEMBL3090521 0.75 FAAH (0.50) FAAHPOLBGBA1NOS3NOS1
SCHEMBL9150 0.74 TMEM97 (0.44) FAAHPOLBGBA1ACE
SCHEMBL317332 0.73 TAAR1 (0.38) POLBGBA1CCR3ACE
SCHEMBL17914399 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2319 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1435957-B1 INHIBITORS OF GSK-3 AND CRYSTAL STRUCTURES OF GSK-3BETA PROTEIN AND PROTEIN COMPLEXES VERTEX PHARMA (US) 2009-06-17 EP claimed
US-20070117041-A1 Photosensitive coating for enhancing a contrast of a photolithographic exposure INFINEON TECHNOLOGIES AG (DE) 2007-05-24 US claimed
US-7125653-B2 Method of producing conductive or semiconducting structured polymers INFINEON TECHNOLOGIES AG (DE) 2006-10-24 US claimed
US-20040242818-A1 Deodorizing agent for sulfur-or nitrogen-containing initiators UCB, S.A. (BE) 2004-12-02 US claimed
EP-1438347-A1 DEODORIZING AGENT FOR SULFUR- OR NITROGEN-CONTAINING INITIATORS UCB, S.A. (BE) 2004-07-21 EP claimed
US-6703190-B2 Method for producing resist structures INFINEON TECHNOLOGIES AG (DE) 2004-03-09 US claimed
EP-1389194-A2 INHIBITORS OF BACE VERTEX PHARMACEUTICALS INCORPORATED (US) 2004-02-18 EP claimed
US-20030152862-A1 Deodorizing agent for sulfur- or nitrogen-containing initiators UCB, S. A. (BE) 2003-08-14 US claimed
US-20030108810-A1 Deodorizing agent for sulfur- or nitrogen-containing salt photoinitiators UCB, S.A. (BE) 2003-06-12 US claimed
EP-1165647-B1 SINGLE COMPONENT ADHESIVE WITH AN ADAPTABLE OPEN JOINT TIME SIEMENS AG (DE) 2003-06-04 EP claimed
WO-2002088101-A2 INHIBITORS OF BACE VERTEX PHARMACEUTICALS INCORPORATED (US) 2002-11-07 WO claimed
US-6288083-B1 ADMINISTERING COMOUNDS SUCH AS 4-(4-CHLOROPHENYL)-1-(4-(3-METHOXYPHENYL)-4-(3-PYRIDINYL)-3 -BUTENYL)PIPERIDIN-4-OL TO TREAT DISEASES ASSOCIATED WITH ABERRANT LEUKOCYTE RECRUITMENT AND/OR ACTIVATION MILLENNIUM PHARMACEUTICALS, INC. 2001-09-11 US claimed
US-6194482-B1 CASTING RESIN OF EPOXY RESIN, ISOCYANURATE SILOXANE, FILLERS, PHOTO INITIATORS AND THERMAL INITIATORS SIEMENS AKTIENGESELLSCHAFT (DE) 2001-02-27 US claimed
US-6150435-A AN EPOXY RESIN COPOLYMER COMPRISING TWO DIFFERENT MOLECULAR WEIGHT POLYOL COMPONENTS; IMPROVE THE PROPERTIES OF COEFFICIENT OF EXPANSION, SHRINKAGE STRESS, SUBSTRATE ADHESION, AND REACTIVITY SIEMENS AKTIENGESELLSCHAFT (DE) 2000-11-21 US claimed
US-6037043-A UV-hardenable and thermally hardenable epoxy resins for underfilling electrical and electronic components SIEMENS AKTIENGESELLSCAFT (DE) 2000-03-14 US claimed
EP-0733689-B1 Chloroprene rubber adhesive composition KONISHI CO LTD (JP) 1998-10-07 EP claimed
EP-0584570-B1 Epoxy resin composition containing sulphonium salts SIEMENS AG (DE) 1998-09-30 EP claimed
EP-0504569-B1 Method of coating or sealing of electronic components or component groups SIEMENS AG (DE) 1997-09-10 EP claimed
EP-0733689-A1 Chloroprene rubber adhesive composition KONISHI CO., LTD. (JP) 1996-09-25 EP claimed
US-5242715-A Cationically hardening solvent-free epoxy resins by heat or uv rad SIEMENS AKTIENGESELLSCHAFT (DE) 1993-09-07 US claimed