Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 5/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2226385 | 0.90 | ALDH1A1 (0.44) | ACHEALOX5ALDH1A1SMN1; SMN2KEAP1 | |
| SCHEMBL10908398 | 0.79 | BRD4 (0.47) | ACHEALOX5ALDH1A1SMN1; SMN2KEAP1 | |
| SCHEMBL1292738 | 0.78 | ACHE (0.47) | HDAC1HDAC8HDAC6STAT3ACHE | |
| SCHEMBL11315150 | 0.75 | AKR1C3 (0.51) | STAT3ACHEALOX5ALDH1A1SMN1; SMN2 | |
| SCHEMBL6884698 | 0.75 | AKR1C3 (0.51) | STAT3ACHEALOX5ALDH1A1SMN1; SMN2 | |
| SCHEMBL3093415 | 0.74 | PTGS2 (0.63) | STAT3ALOX5ALDH1A1LMNAAKR1C3 | |
| SCHEMBL597882 | 0.74 | PTGS2 (0.63) | STAT3ALOX5ALDH1A1LMNAAKR1C3 | |
| SCHEMBL349312 | 0.74 | PTGS2 (0.63) | STAT3ALOX5ALDH1A1LMNAAKR1C3 | |
| SCHEMBL17084165 | 0.74 | HDAC1 (0.39) | HDAC1HDAC8HDAC6STAT3ACHE | |
| SCHEMBL17084093 | 0.74 | HDAC1 (0.39) | HDAC1HDAC8HDAC6STAT3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5554624-A | CONGESTIVE HEART FAILURE; HYPOTENSIVE AGENTS | J. URIACH & CIA. (ES) | 1996-09-10 | — | — | US | disclosed |
| EP-0669333-A1 | New imidazopyridine derivatives as angiotensin II antagonists | J. URIACH & CIA. S.A. (ES) | 1995-08-30 | — | — | EP | disclosed |