Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 9/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.52 |
| ▸ | ESRRG | P62508 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TYR | P14679 | 1/20 | 0.52 |
| ▸ | AR | P10275 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SHBG | P04278 | 1/20 | 0.43 |
| ▸ | PGK1 | P00558 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9502470 | 0.84 | PTPN5 (0.50) | PGK1PGK2 | |
| SCHEMBL11759829 | 0.82 | TSHR (0.48) | CYP3A4LMNAHPGDTSHRMEN1 | |
| SCHEMBL17923871 | 0.80 | PGK1 (0.46) | MEN1KMT2APGK1PGK2 | |
| SCHEMBL2637396 | 0.80 | FDPS (0.47) | ESRRGCYP3A4LMNAHPGDMEN1 | |
| Bisphenol A SCHEMBL29411202 | 0.79 | ESR1 (0.76) | ESR1ESR2ESRRGCYP3A4LMNA | |
| SCHEMBL1099732 | 0.79 | PTPN1 (0.58) | ESR1ESR2CYP3A4TSHRKMT2A | |
| Phosphoric Acid SCHEMBL28888202 | 0.79 | LMNA (0.76) | ESR1ESR2ESRRGCYP3A4LMNA | |
| Bisphenol A SCHEMBL9280917 | 0.79 | ESR1 (0.76) | ESR1ESR2ESRRGCYP3A4LMNA | |
| Phosphoric Acid SCHEMBL10743913 | 0.79 | LMNA (0.76) | ESR1ESR2ESRRGCYP3A4LMNA | |
| SCHEMBL25411987 | 0.78 | KDM4E (0.48) | ESR1ESR2ESRRGCYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5484780-A | CARDIOVASCULAR, HYPOTENSIVE | ELI LILLY AND COMPANY (US) | 1996-01-16 | — | — | US | disclosed |
| US-5401851-A | Preparation of proline derivatives | ELI LILLY AND COMPANY (US) | 1995-03-28 | — | — | US | disclosed |
| EP-0573271-A1 | Angiotensin II antagonists | ELI LILLY AND COMPANY (US) | 1993-12-08 | — | — | EP | disclosed |