Water

Water

SCHEMBL9000149

CCCCCCCCCCCC[n+]1cccc(C(=O)O)c1.[OH-]

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 3/20 0.67
LMNA P02545 2/20 0.67
APAF1 O14727 2/20 0.67
SMN1; SMN2 Q16637 1/20 0.67
RAD52 P43351 1/20 0.67
USP2 O75604 1/20 0.67
ALDH1A1 P00352 1/20 0.67
XBP1 P17861 1/20 0.67
HTT P42858 1/20 0.67
BLM P54132 1/20 0.67
NPSR1 Q6W5P4 1/20 0.67
ABCB11 O95342 1/20 0.51
ESR1 P03372 1/20 0.51
PGR P06401 1/20 0.51
CHRM2 P08172 1/20 0.51
HTR1A P08908 1/20 0.51
ADRA2A P08913 1/20 0.51
ADORA3 P0DMS8 1/20 0.51
CHRM1 P11229 1/20 0.51
DRD1 P21728 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14387168 0.98 HSP90AA1 (0.68) HSP90AA1LMNAAPAF1SMN1; SMN2RAD52
SCHEMBL31023557 0.98 HSP90AA1 (0.68) HSP90AA1LMNAAPAF1SMN1; SMN2RAD52
Iodide SCHEMBL1788625 0.97 HSP90AA1 (0.67) HSP90AA1LMNAAPAF1SMN1; SMN2RAD52
Iodide SCHEMBL1787088 0.97 HSP90AA1 (0.67) HSP90AA1LMNAAPAF1SMN1; SMN2RAD52
SCHEMBL10307404 0.92 HSP90AA1 (0.59) HSP90AA1LMNAAPAF1SMN1; SMN2RAD52
Iodide SCHEMBL1789963 0.91 HSP90AA1 (0.58) HSP90AA1LMNAAPAF1SMN1; SMN2RAD52
Bromide SCHEMBL17906580 0.91 HSP90AA1 (0.62) HSP90AA1LMNAAPAF1SMN1; SMN2RAD52
SCHEMBL14075499 0.91 LMNA (0.56) HSP90AA1LMNAAPAF1SMN1; SMN2RAD52
SCHEMBL23074606 0.89 HSP90AA1 (0.62) HSP90AA1LMNAAPAF1SMN1; SMN2RAD52
SCHEMBL27450252 0.88 HSP90AA1 (0.60) HSP90AA1LMNAAPAF1SMN1; SMN2RAD52

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105658322-B Clay/polymer blends as high pH or ionic liquid barriers 艾莫考国际公司 2021-04-09 CN claimed
EP-3019271-A1 CLAY/POLYMER BLEND AS HIGH PH OR IONIC LIQUID BARRIER Amcol International Corporation (US) 2016-05-18 EP claimed
WO-2015006746-A1 CLAY/POLYMER BLEND AS HIGH PH OR IONIC LIQUID BARRIER AMCOL INTERNATIONAL CORPORATION (US) 2015-01-15 WO claimed
CN-105658322-B Clay/polymer blends as high pH or ionic liquid barriers 艾莫考国际公司 2021-04-09 CN disclosed
EP-3778523-A1 CLAY/POLYMER BLEND AS HIGH PH OR IONIC LIQUID BARRIER AMCOL INTERNATIONAL CORPORATION (US) 2021-02-17 EP disclosed
US-9403974-B2 Clay/polymer blend as high pH or ionic liquid barrier AMCOL INTERNATIONAL CORPORATION (US) 2016-08-02 US disclosed
EP-3019271-A1 CLAY/POLYMER BLEND AS HIGH PH OR IONIC LIQUID BARRIER Amcol International Corporation (US) 2016-05-18 EP disclosed
WO-2015006746-A1 CLAY/POLYMER BLEND AS HIGH PH OR IONIC LIQUID BARRIER AMCOL INTERNATIONAL CORPORATION (US) 2015-01-15 WO disclosed
EP-0445627-B1 Silver halide photographic light-sensitive materials FUJI PHOTO FILM CO LTD (JP) 1996-09-11 EP disclosed
EP-0445627-A1 Silver halide photographic light-sensitive materials FUJI PHOTO FILM CO., LTD. (JP) 1991-09-11 EP disclosed