Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 6/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | PTAFR | P25105 | 2/20 | 0.34 |
| ▸ | ECE1 | P42892 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000575 | 0.92 | SOAT1 (0.39) | SOAT1ALDH1A1 | |
| SCHEMBL9000651 | 0.86 | SOAT1 (0.41) | SOAT1ALDH1A1POLB | |
| SCHEMBL9000713 | 0.86 | EPHX1 (0.43) | GSK3BLMNASOAT1ALDH1A1POLB | |
| SCHEMBL9000506 | 0.85 | SOAT1 (0.39) | LMNASOAT1ALDH1A1RAB9APOLB | |
| SCHEMBL9000898 | 0.85 | EPHX1 (0.46) | SOAT1ALDH1A1NPC1RAB9A | |
| SCHEMBL9000753 | 0.84 | SOAT1 (0.39) | LMNASOAT1ALDH1A1NPC1RAB9A | |
| SCHEMBL9000445 | 0.84 | POLB (0.43) | GSK3BLMNASOAT1ALDH1A1POLB | |
| SCHEMBL9000398 | 0.82 | EPHX1 (0.47) | LMNASOAT1NPC1RAB9A | |
| SCHEMBL9000588 | 0.82 | EPHX1 (0.38) | LMNASOAT1ALDH1A1 | |
| SCHEMBL9000604 | 0.82 | EPHX1 (0.47) | SOAT1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |