Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 6/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | VCP | P55072 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000651 | 0.94 | SOAT1 (0.41) | SOAT1NPSR1ALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL9000713 | 0.94 | EPHX1 (0.43) | SOAT1NPSR1ALDH1A1PKMKMT2A | |
| SCHEMBL9000506 | 0.92 | SOAT1 (0.39) | SOAT1NPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9000898 | 0.92 | EPHX1 (0.46) | SOAT1ALDH1A1KMT2ACYP3A4KDM4E | |
| SCHEMBL9000520 | 0.92 | GSK3B (0.37) | SOAT1ALDH1A1 | |
| SCHEMBL9000445 | 0.91 | POLB (0.43) | SOAT1ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL9000753 | 0.91 | SOAT1 (0.39) | SOAT1NPSR1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL9000604 | 0.90 | EPHX1 (0.47) | SOAT1ALDH1A1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL9000398 | 0.90 | EPHX1 (0.47) | SOAT1PKMKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL9000588 | 0.90 | EPHX1 (0.38) | SOAT1ALDH1A1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |