Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000777 | 0.95 | KMT2A (0.37) | SOAT1KMT2AMEN1POLBLMNA | |
| SCHEMBL9000506 | 0.93 | SOAT1 (0.39) | SOAT1POLBLMNAALDH1A1RAB9A | |
| SCHEMBL9000651 | 0.93 | SOAT1 (0.41) | SOAT1POLBALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL9000831 | 0.93 | TOP2A (0.37) | SOAT1KMT2AMEN1POLBLMNA | |
| SCHEMBL9000608 | 0.92 | FNTA (0.37) | SOAT1KMT2ALMNANPSR1EPHX1 | |
| SCHEMBL9000575 | 0.91 | SOAT1 (0.39) | SOAT1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL9000497 | 0.91 | EPHX1 (0.38) | SOAT1KMT2AMEN1POLBLMNA | |
| SCHEMBL9000839 | 0.91 | SOAT1 (0.38) | SOAT1KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL9000445 | 0.91 | POLB (0.43) | SOAT1KMT2AMEN1POLBLMNA | |
| SCHEMBL9000701 | 0.89 | EPHX1 (0.41) | SOAT1KMT2AMEN1POLBEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |