Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 5/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000888 | 0.95 | EPHX1 (0.44) | EPHX1SCN9ASOAT1EGFRMET | |
| SCHEMBL9000777 | 0.94 | KMT2A (0.37) | MEN1KMT2ACYP1A2SOAT1POLB | |
| SCHEMBL9000604 | 0.91 | EPHX1 (0.47) | EPHX1MEN1KMT2ACYP1A2SCN9A | |
| SCHEMBL9000831 | 0.91 | TOP2A (0.37) | MEN1KMT2ASOAT1POLBEGFR | |
| SCHEMBL9000497 | 0.89 | EPHX1 (0.38) | EPHX1MEN1KMT2ASOAT1POLB | |
| SCHEMBL9000753 | 0.89 | SOAT1 (0.39) | EPHX1MEN1KMT2ASOAT1POLB | |
| SCHEMBL9000768 | 0.88 | EPHX1 (0.41) | EPHX1CYP1A2 | |
| SCHEMBL9000610 | 0.87 | CTRC (0.39) | MEN1KMT2ASOAT1POLB | |
| SCHEMBL9000608 | 0.85 | FNTA (0.37) | EPHX1KMT2ASOAT1 | |
| SCHEMBL9000745 | 0.84 | EPHX1 (0.41) | EPHX1MEN1KMT2ASOAT1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |