Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 6/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000671 | 0.91 | EPHX1 (0.34) | SOAT1MAPTLMNAHTTMEN1 | |
| SCHEMBL9000753 | 0.91 | SOAT1 (0.39) | SOAT1MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL9000506 | 0.90 | SOAT1 (0.39) | SOAT1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL9000708 | 0.90 | EPHX1 (0.38) | MAPTLMNAHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL9000651 | 0.90 | SOAT1 (0.41) | SOAT1CYP3A4ALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL9000575 | 0.88 | SOAT1 (0.39) | SOAT1CYP3A4MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9000445 | 0.87 | POLB (0.43) | SOAT1MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL9000777 | 0.86 | KMT2A (0.37) | SOAT1CYP3A4LMNAMEN1CYP1A2 | |
| SCHEMBL9000787 | 0.86 | LMNA (0.46) | SOAT1MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL9000604 | 0.85 | EPHX1 (0.47) | SOAT1CYP3A4MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |