Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000458 | 0.90 | EPHX1 (0.41) | SMN1; SMN2ABCB1EPHX1MAPTLMNA | |
| SCHEMBL9000878 | 0.90 | EPHX1 (0.41) | SMN1; SMN2ABCB1EPHX1MAPTLMNA | |
| SCHEMBL9000423 | 0.87 | EPHX1 (0.44) | SMN1; SMN2EPHX1MAPTLMNAMMP13 | |
| SCHEMBL9000745 | 0.83 | EPHX1 (0.41) | POLBSMN1; SMN2RAB9AABCB1EPHX1 | |
| SCHEMBL9000768 | 0.83 | EPHX1 (0.41) | SMN1; SMN2EPHX1MAPTLMNAMMP13 | |
| SCHEMBL9000398 | 0.82 | EPHX1 (0.47) | SMN1; SMN2NPC1RAB9AEPHX1MAPT | |
| SCHEMBL9000786 | 0.81 | KMT2A (0.38) | POLBSMN1; SMN2EPHX1MAPTLMNA | |
| SCHEMBL9000898 | 0.81 | EPHX1 (0.46) | NPC1RAB9AEPHX1MAPTL3MBTL1 | |
| SCHEMBL9000708 | 0.81 | EPHX1 (0.38) | SMN1; SMN2EPHX1MAPTLMNAMMP13 | |
| SCHEMBL9000809 | 0.80 | SOAT1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |