Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | LMNA | P02545 | 7/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000530 | 1.00 | MAPT (0.41) | MAPTLMNAHTTALDH1A1NPSR1 | |
| SCHEMBL9000592 | 0.95 | MAPT (0.44) | MAPTLMNAHTTALDH1A1NPSR1 | |
| SCHEMBL9000902 | 0.93 | MAPT (0.42) | MAPTLMNAMEN1KMT2AGAA | |
| SCHEMBL9000642 | 0.91 | MAPT (0.41) | MAPTLMNAHTTALDH1A1NPSR1 | |
| SCHEMBL9000852 | 0.91 | MAPT (0.52) | MAPTLMNAHTTALDH1A1NPSR1 | |
| SCHEMBL9000802 | 0.90 | MAPT (0.39) | MAPTLMNAHTTALDH1A1NPSR1 | |
| SCHEMBL9000887 | 0.89 | LMNA (0.39) | MAPTLMNANPSR1SMN1; SMN2MEN1 | |
| SCHEMBL9000950 | 0.89 | MAPT (0.46) | MAPTLMNAHTTALDH1A1NPSR1 | |
| SCHEMBL9000744 | 0.87 | MAPT (0.38) | MAPTLMNAALDH1A1NPSR1MEN1 | |
| SCHEMBL9000878 | 0.86 | EPHX1 (0.41) | MAPTLMNAHTTALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |