Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 8/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.37 |
| ▸ | S100A10 | P60903 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000592 | 0.93 | MAPT (0.44) | MAPTLMNAALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL9000883 | 0.90 | MAPT (0.41) | MAPTLMNAALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL9000744 | 0.90 | MAPT (0.38) | MAPTLMNAALDH1A1NPSR1PDE2A | |
| SCHEMBL9000530 | 0.90 | MAPT (0.41) | MAPTLMNAALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL9000642 | 0.88 | MAPT (0.41) | MAPTLMNAALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL9000852 | 0.88 | MAPT (0.52) | MAPTLMNAALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL9000593 | 0.87 | PDE2A (0.43) | MAPTALDH1A1PDE2AANXA2S100A10 | |
| SCHEMBL9000902 | 0.83 | MAPT (0.42) | MAPTLMNAMEN1KMT2A | |
| SCHEMBL9000423 | 0.79 | EPHX1 (0.44) | MAPTLMNAALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL9000887 | 0.79 | LMNA (0.39) | MAPTLMNASMN1; SMN2NPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |