Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 5/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000505 | 0.89 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2SLC2A1MEN1KMT2A | |
| SCHEMBL9000864 | 0.87 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2SLC2A1MEN1KMT2A | |
| SCHEMBL9000950 | 0.85 | MAPT (0.46) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL9000450 | 0.85 | SOAT1 (0.41) | ALDH1A1MEN1KMT2ALMNAGAA | |
| SCHEMBL9000445 | 0.83 | POLB (0.43) | ALDH1A1MEN1KMT2ALMNAGAA | |
| SCHEMBL9000902 | 0.82 | MAPT (0.42) | MEN1KMT2ALMNAGAAMAPT | |
| SCHEMBL9000713 | 0.80 | EPHX1 (0.43) | ALDH1A1MEN1KMT2ALMNAGAA | |
| SCHEMBL9000745 | 0.79 | EPHX1 (0.41) | SMN1; SMN2MEN1KMT2ALMNAGAA | |
| SCHEMBL9000815 | 0.79 | MAPT (0.50) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL9000853 | 0.78 | SOAT1 (0.42) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |