Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KLK7 | P49862 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000505 | 0.87 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2CNR1CNR2NPSR1 | |
| SCHEMBL9000852 | 0.86 | MAPT (0.52) | ALDH1A1SMN1; SMN2NPSR1KMT2AMEN1 | |
| SCHEMBL9000409 | 0.85 | TRPV1 (0.40) | SMN1; SMN2CNR2KMT2AMEN1NPC1 | |
| SCHEMBL9000398 | 0.84 | EPHX1 (0.47) | SMN1; SMN2CNR2KMT2AMEN1NPC1 | |
| SCHEMBL9000592 | 0.82 | MAPT (0.44) | ALDH1A1SMN1; SMN2NPSR1KMT2AMEN1 | |
| SCHEMBL9000898 | 0.81 | EPHX1 (0.46) | ALDH1A1ADORA3KMT2ANPC1RAB9A | |
| SCHEMBL9000423 | 0.80 | EPHX1 (0.44) | ALDH1A1SMN1; SMN2NPSR1KMT2AMEN1 | |
| SCHEMBL9000883 | 0.79 | MAPT (0.41) | ALDH1A1SMN1; SMN2NPSR1KMT2AMEN1 | |
| SCHEMBL9000642 | 0.79 | MAPT (0.41) | ALDH1A1SMN1; SMN2CNR2NPSR1KMT2A | |
| SCHEMBL9000530 | 0.79 | MAPT (0.41) | ALDH1A1SMN1; SMN2NPSR1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |