Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 6/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.33 |
| ▸ | RBP4 | P02753 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000803 | 0.86 | SOAT1 (0.37) | SOAT1 | |
| SCHEMBL9000614 | 0.84 | SOAT1 (0.38) | SOAT1ALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL9000515 | 0.80 | SOAT1 (0.36) | SOAT1HPGDKDM4E | |
| SCHEMBL9000583 | 0.78 | KDM1A (0.37) | SOAT1ALDH1A1HPGDKDM4E | |
| SCHEMBL9001010 | 0.74 | SOAT1 (0.43) | SOAT1ALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL9000419 | 0.74 | SOAT1 (0.41) | SOAT1RAB9A | |
| SCHEMBL9000550 | 0.71 | SORT1 (0.40) | SOAT1 | |
| SCHEMBL9008215 | 0.71 | SOAT1 (0.41) | SOAT1ALDH1A1 | |
| SCHEMBL9000766 | 0.70 | SOAT1 (0.38) | SOAT1HPGD | |
| SCHEMBL9000743 | 0.70 | SOAT1 (0.38) | SOAT1RAB9ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |