Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 4/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 6/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000766 | 0.91 | SOAT1 (0.38) | SORT1SOAT1KMT2A | |
| SCHEMBL9000743 | 0.91 | SOAT1 (0.38) | SORT1SOAT1KMT2ATP53 | |
| SCHEMBL9000419 | 0.89 | SOAT1 (0.41) | SORT1SOAT1LMNAKMT2ANTRK1 | |
| SCHEMBL9000644 | 0.85 | PLK1 (0.38) | SOAT1LMNATSHRKMT2A | |
| SCHEMBL9000590 | 0.84 | PHGDH (0.40) | SORT1SOAT1PHGDHLMNAKMT2A | |
| SCHEMBL9001010 | 0.77 | SOAT1 (0.43) | SOAT1LMNAKMT2ANTRK1 | |
| SCHEMBL9000775 | 0.76 | SORT1 (0.36) | SORT1PHGDH | |
| SCHEMBL9000652 | 0.76 | SOAT1 (0.40) | SOAT1TSHRKMT2A | |
| SCHEMBL9000744 | 0.76 | MAPT (0.38) | SOAT1LMNAKMT2ANTRK1NTRK2 | |
| SCHEMBL32667998 | 0.75 | CYP1A2 (0.50) | SOAT1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |