Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 6/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000550 | 0.89 | SORT1 (0.40) | SOAT1SORT1KMT2ALMNANTRK1 | |
| SCHEMBL9000766 | 0.87 | SOAT1 (0.38) | SOAT1SORT1MEN1KMT2A | |
| SCHEMBL9000743 | 0.87 | SOAT1 (0.38) | SOAT1SORT1MEN1KMT2APOLB | |
| SCHEMBL9001013 | 0.85 | MAPT (0.42) | SOAT1MEN1KMT2A | |
| SCHEMBL9000644 | 0.81 | PLK1 (0.38) | SOAT1MEN1KMT2ALMNANPC1 | |
| SCHEMBL9001010 | 0.81 | SOAT1 (0.43) | SOAT1MEN1KMT2ALMNANPC1 | |
| SCHEMBL9000583 | 0.81 | KDM1A (0.37) | SOAT1DHODHHDAC1HDAC8HDAC6 | |
| SCHEMBL9000669 | 0.79 | GRM5 (0.43) | SOAT1GRM5HDAC1HDAC8HDAC6 | |
| SCHEMBL9000652 | 0.76 | SOAT1 (0.40) | SOAT1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL9000682 | 0.74 | SOAT1 (0.40) | SOAT1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |