Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9002210 | 0.93 | SMN1; SMN2 (0.38) | HTTSMN1; SMN2POLBHPGDEPHX2 | |
| SCHEMBL9002613 | 0.91 | CNR2 (0.37) | POLBKDM4EALDH1A1GAACDK8 | |
| SCHEMBL9002400 | 0.87 | MTNR1A (0.35) | SMN1; SMN2POLBHPGDALDH1A1GAA | |
| SCHEMBL9189084 | 0.86 | POLB (0.42) | HTTPOLBHPGDEPHX2ALDH1A1 | |
| SCHEMBL9002520 | 0.85 | ACHE (0.43) | HTTSMN1; SMN2POLBHPGDEPHX2 | |
| SCHEMBL9001920 | 0.84 | MTNR1A (0.47) | ALDH1A1TSHRCDK8 | |
| SCHEMBL9002397 | 0.84 | ALDH1A1 (0.36) | POLBKDM4EALDH1A1GAAEPHX1 | |
| SCHEMBL9001977 | 0.82 | MTNR1B (0.37) | SMN1; SMN2HPGDKDM4EALDH1A1NPC1 | |
| SCHEMBL9001857 | 0.82 | HPGD (0.34) | HTTSMN1; SMN2POLBHPGDEPHX2 | |
| SCHEMBL9002309 | 0.82 | SMN1; SMN2 (0.37) | HTTSMN1; SMN2POLBHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5587383-A | CALMODULIN INHIBITORS; ANTIISCHEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-12-24 | — | — | US | disclosed |
| EP-0471236-B1 | Imidazopyridine derivatives and their use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-03-15 | — | — | EP | disclosed |
| US-5395839-A | Calmodulin and angiogenesis inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-03-07 | — | — | US | disclosed |
| US-5244908-A | Calmodulin inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-09-14 | — | — | US | disclosed |
| EP-0471236-A1 | Imidazopyridine derivatives and their use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-02-19 | — | — | EP | disclosed |