Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | CES2 | O00748 | 1/20 | 0.58 |
| ▸ | CES1 | P23141 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17303445 | 0.84 | TSHR (0.77) | MAPTALDH1A1SMN1; SMN2CES2CES1 | |
| SCHEMBL11716099 | 0.84 | LMNA (0.56) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11709876 | 0.84 | VCAM1 (0.70) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL10554801 | 0.83 | ALDH1A1 (0.61) | MAPTALDH1A1SMN1; SMN2TSHRKMT2A | |
| SCHEMBL8408501 | 0.83 | CES2 (0.77) | MAPTALDH1A1SMN1; SMN2CES2CES1 | |
| SCHEMBL5175961 | 0.80 | RAB9A (0.70) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7386856 | 0.79 | LMNA (0.48) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8943367 | 0.79 | MAPT (0.47) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2900922 | 0.79 | MAPT (0.60) | MAPTALDH1A1SMN1; SMN2CES2CES1 | |
| SCHEMBL7373087 | 0.78 | TTR (0.59) | MAPTALDH1A1SMN1; SMN2TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5482948-A | Pyridyl derivatives and pharmaceutical compositions comprising these compounds | DR. KARL THOMAE GMBH (DE) | 1996-01-09 | — | — | US | disclosed |
| EP-0547517-B1 | Pyridyl derivatives, medicines containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-05-17 | — | — | EP | disclosed |
| EP-0547517-A1 | Pyridyl derivatives, medicines containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-06-23 | — | — | EP | disclosed |