Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | P2RX1 | P51575 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RORB | Q92753 | 3/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9002865 | 0.79 | PDE4D (0.61) | RORBPDE4DMAPTNPC1RAB9A | |
| SCHEMBL9002267 | 0.78 | RORB (0.56) | TRPV1RORBLMNATDP1PKM | |
| SCHEMBL9002089 | 0.75 | NR2E1 (0.46) | TRPV1P2RX1RORBP2RX4P2RX7 | |
| SCHEMBL10768030 | 0.70 | PDE4D (0.60) | TP53PDE4DMAPTNPC1RAB9A | |
| SCHEMBL7273341 | 0.70 | PDE4D (0.60) | TP53PDE4DMAPTNPC1RAB9A | |
| SCHEMBL27993567 | 0.69 | KMT2A (0.60) | PDE4DMAPTNPC1RAB9ATDP1 | |
| SCHEMBL9002388 | 0.69 | GPBAR1 (0.52) | MAPTHTTLMNAGPBAR1MEN1 | |
| SCHEMBL30600332 | 0.69 | CYP19A1 (0.64) | P2RX1MAPTLMNATDP1SCN2A | |
| SCHEMBL473595 | 0.69 | ALDH1A1 (0.59) | TRPV1RORBLMNARAB9ATDP1 | |
| SCHEMBL29319717 | 0.68 | CYP19A1 (0.48) | P2RX1P2RX4P2RX7HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5482948-A | Pyridyl derivatives and pharmaceutical compositions comprising these compounds | DR. KARL THOMAE GMBH (DE) | 1996-01-09 | — | — | US | disclosed |