Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 | P47869 | 4/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9003413 | 0.98 | GABRA2 (0.36) | GABRA2GABRB2CYP3A4MAPK1MAPT | |
| SCHEMBL8757368 | 0.87 | GABRA2 (0.32) | GABRA2GABRB2CYP3A4MAPK1MAPT | |
| SCHEMBL5898308 | 0.79 | LMNA (0.41) | CYP3A4MAPK1IDO1ALDH1A1TSHR | |
| SCHEMBL6715464 | 0.78 | TLR8 (0.42) | GABRA2GABRB2MAPK1MAPTCTSS | |
| Tetramethylammonium Ion SCHEMBL1130664 | 0.75 | TLR8 (0.40) | GABRA2GABRB2MAPK1MAPTCTSS | |
| SCHEMBL26287035 | 0.75 | TLR8 (0.40) | CYP3A4MAPTCTSSCTSKALDH1A1 | |
| Biphenyl SCHEMBL7785983 | 0.73 | TLR8 (0.41) | CYP3A4MAPTCTSSCTSKTSHR | |
| Tetrabuthylammonium SCHEMBL1130718 | 0.73 | TLR8 (0.39) | GABRA2GABRB2CTSSCTSKALDH1A1 | |
| Butylamine SCHEMBL628202 | 0.73 | CYP3A4 (0.36) | GABRA2GABRB2CYP3A4MAPK1MAPT | |
| SCHEMBL26287046 | 0.72 | NFE2L2 (0.40) | MAPTCTSSCTSKALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500453-A | INITIATOR FOR PHOTOSENSITIVE FREE RADICAL CURING/ POLYMERIZATION OF UNSATURATED COMPOUNDS | TOYO INK MANUFACTURING CO., LTD. (JP) | 1996-03-19 | — | — | US | disclosed |
| EP-0555058-A1 | (Oxo)sulfonium complex, polymerizable composition containing the complex, and method of polymerizing composition | TOYO INK MANUFACTURING CO., LTD. (JP) | 1993-08-11 | — | — | EP | disclosed |